Professor Twerski is a preeminent authority in the areas of products liability and tort law. The American Bar Association's Tort Trial Insurance Practice Section honored him with the 2007 Robert B. McKay Law Professor Award, which recognizes law professors who are committed to the advancement of justice, scholarship, and the legal profession in the fields of tort and insurance law. He was Co-Reporter for the American Law Institute's Restatement of the Law (Third) Torts: Products Liability, published in 1998. For his distinguished performance as a Reporter, the ALI named him the R. Ammi Cutter Reporter.

He is a prolific scholar, having published dozens of law review articles on torts and products liability law. Among his recent articles are those published in the Yale Law Journal, Cornell Law Review, New York University Law Review, Northwestern University Law Review, and the Georgetown Law Journal. He is also the author of the leading textbook, Products Liability: Problems and Process (4th ed. 2000) (with J. Henderson, Jr.).

His expertise has been widely called upon by state and federal legislative bodies considering product liability and mass tort legislation, and he is a frequent lecturer to the practicing bar. He joined the faculty in 1986, after serving as Interim Dean at Hofstra University School of Law, where he taught for many years. He also taught at Duquesne University School of Law and was a Visiting Professor at Cornell, Boston University, and the University of Michigan law schools. His background also includes a teaching fellowship at Harvard Law School and work as a trial attorney with the U.S. Department of Justice in its Civil Rights Division.